Premier League champions Manchester City will start the defence of their title away to Tottenham after the fixtures for the 2021/22 season were unveiled on Wednesday.
City are among the sides heavily linked with Spurs striker Harry Kane, throwing up the tantalising possibility that the England captain could line up against his boyhood club on the opening weekend.
Pep Guardiola's side won the league by 12 points last season ahead of rivals Manchester United, who open their campaign against old foes Leeds at Old Trafford.
Both clashes were played behind closed doors on Leeds' return to the top flight last season, but hopes are high for significant crowd numbers for the coming season.
A 40,000 crowd will witness the Euro 2020 semi-finals and final at Wembley in July as part of a UK government pilot scheme.
Elsewhere on the weekend of August 14, new boys Brentford begin life back in the top flight for the first time in 75 years with a London derby at home to Arsenal, while Championship winners Norwich entertain Liverpool on their return to the Premier League.
Champions League winners Chelsea welcome managerless Crystal Palace to Stamford Bridge
There are a number of early meetings between the 'big six'. Liverpool host Chelsea on the third weekend of the season before the Blues host Manchester City in a repeat of the Champions League final on September 25.
Liverpool renew their rivalry with City on October 2 at Anfield and their clash at the Etihad on April 9 could be key in the title race.
United and Liverpool face off at Old Trafford on October 23 and March 19 at Anfield.
All fixtures are still subject to change for TV coverage.
Opening weekend fixtures | Kicks off on August 14:
Brentford vs Arsenal
Burnley vs Brighton
Chelsea vs Crystal Palace
Everton vs Southampton
Leicester City vs Wolverhampton
Manchester United vs Leeds United
Newcastle United vs West Ham United
Norwich City vs Liverpool
Tottenham Hotspur vs Manchester City
Watford vs Aston Villa
Boxing day games | The clashes lined up for December 26:
Aston Villa vs Chelsea
Brighton vs Brentford
Burnley vs Everton
Liverpool vs Leeds United
Manchester City vs Leicester City
Newcastle United vs Manchester United
Norwich City vs Arsenal
Tottenham Hotspur vs Crystal Palace
West Ham United vs Southampton
Wolverhampton vs Watford
Final matchday 38 | The weekend of May 22
Arsenal vs Everton
Brentford vs Leeds United
Brighton vs West Ham United
Burnley vs Newcastle United
Chelsea vs Watford
Crystal Palace vs Manchester United
Leicester City vs Southampton
Liverpool vs Wolverhampton
Manchester City vs Aston Villa
Norwich City vs Tottenham Hotspur