Eight Montpellier players and four backroom staff have tested positive for Covid-19, the club said Friday, putting in doubt their weekend Ligue 1 game against Monaco.
The entire squad underwent further tests on Friday while the 12 who tested positive have been put in isolation, according to the club.
Michel Der Zakarian's team, currently fifth in Ligue 1, are scheduled to play away at Monaco on Sunday.
Since the coronavirus pandemic erupted, seven players at Montpellier tested positive.
Midfielder Junior Sambia, who was hospitalised and put in an artificial coma in April, was the first known Ligue 1 player to have contracted the virus.
The 24-year-old has recovered and has made several appearances for the team in the new season.
The players reported to have tested positive are two goalkeepers, its entire starting defence and the club's best two attacking players Andy Delort and Teji Savanier.
Head coach Der Zakarian is also reported to be one of the four staff members to have returned a positive result.
Bafana Bafana's Keagan Dolly is not believed to be one of the players to have tested positive.