The Red Devils are targeting their first win in eight PL away matches (D3 L4). They last had a longer such winless run in the top flight between February and September 1989, with 11 matches.
Newcastle are aiming to avoid this becoming the fifth top-flight season in which they fail to win any of their first four home matches, after 1898/99, 1905/06, 2015/16 and 2018/19.
Man Utd have won 13 PL away matches at Newcastle. They have only won more at Aston Villa and Everton, with 15 and 16 respectively.
This will be Steve Bruce’s 400th Premier League match (W111 D111 L177) but the Newcastle head coach is looking for a first win over Man Utd at the 22nd attempt.
Man Utd substitutes: Romero (GK), Williams, Rojo, Matic, Gomes, Chong, Greenwood.
Man Utd starting XI: De Gea; Dalot, Tuanzebe, Maguire, Young; Fred, McTominay, Andreas; Mata, Rashford, James.
Newcastle United subs: Darlow (GK), Krafth Dummett, Shelvey, Atsu, Gayle, Carroll.
Newcastle United starting XI: Dubravka; Yedlin, Schar, Lascelles, Clark, Willems; M. Longstaff, S. Longstaff; Saint-Maximin, Joelinton, Almiron.
Hello and welcome to today's live coverage of the Premier League match between Newcastle United and Manchester United. Kickoff is at 4.30pm UK time.
Saint-Maximin makes a great dribble for Newcastle through Man Utd's midfield and finds Almorin, but Young does well to block the cross.
We are underway at St. James Park at Newcastle get the game started.
Newcastle attack again as Almorin links with Joelinton but he gets fouled by Fred who pulls him back.
Schar drives the resulting freekick into the wall as the chance comes to nothing.
Newcastle are starting brothers, Sean and Matty Longstaff together in midfield today.
Man Utd close down Dubravka well and the Newcastle goalkeeper puts the ball straight out for a throw-in.
Man Utd are keeping the ball well here to take the string out of Newcastle's fast start.
Newcastle go direct and Joelinton wins a good flick-on against Tuanzebe but the ball runs through to De Gea.
Saint-Maximin makes another good dribble for Newcastle as he cuts inside from the left and fires off a shot but it lacks power and accuracy and goes wide.
Matty James brings down DeAndre Yedlin on his forward run and is perhaps fortunate to avoid a yellow card.
Yellow - Yedlin goes into the book for Newcastle for a foul on McTominay, but replays show there was no contact.
Axel Tuanzebe fouls Joelinton as they challenge for a high ball. The Newcastle forward is proving a handful in the air so far.
Man Utd string together their first decent attack with some quick interplay, but Juan Mata was offside and the move comes to nothing.
Saint-Maximin shows Andreas a clear set of heels but he can't find Joelinton with his pass. The winger is looking lively but is yet to produce any end product.
Schar fouls Matty James on the right and United have a freekick into a good position for Young to deliver.
Matty Longstaff fouls Matty James and Young gets another chance to deliver for Man Utd, but Ciaran Clark heads the delivery clear.
Ashley Young whips the cross in, but Dubravka catches well. That's a disappointing delivery by the Man Utd captain.
The away side gives the ball away and Harry Maguire has to make a good intervention to prevent a through ball reaching Joelinton's run.
Mata does well and links with Young for The Red Devils and the latter delivers a good cross from the left, but Clark heads clear again.
Young lofts a corner into the Newcastle box and Dubravka claims well. That's another below-par delivery from a dead-ball situation by the Man Utd left back.
Close! Matty Longstaff receives from Saint-Maximin and volleys a shot towards goal which smashes off the crossbar. Unlucky for the 19 year old.
Close again! From a corner, Schar heads just over the bar from Sean Longstaff's delivery. Newcastle are looking the more dangerous side here so far.
Yellow - Scott McTominay catches Sean Longstaff with a late tackle and goes into the book. That was not the best challenge.
VAR has checked that challenge to see if it was worthy of a red card but the referee's decision has been upheld. That is probably the correct decision.
Saint-Maximin takes on Dalot on Newcastle's left and the Man United right-back has to make a sliding tackle inside the box which he times to perfection.
Schar and Young both need treatment after they clash heads from a Newcastle corner, but both players look fine to continue.
Tuanzebe gives the ball away for Solskjaer's side and Newcastle try to counter attack, but the young Man Utd defender recovers well with strong defending.
Fred tries a pass around the corner but there is no teammate anywhere near his pass and it runs through to Dubravka.
Chance! Newcastle send Almiron through on goal for a clear opening but the Paraguayan attacker takes far too long to get a shot away and it instead gets blocked. That's very wasteful by the home side.
A decent opening for Man Utd as Maguire picks out Andreas for a shot, but his effort is too close to Dubravka, who saved well.
Newcastle have had seven shots so far compared to just two for Man Utd.
Newcastle attack up the right... Almiron crosses, Joelinton flicks on, and Willems drives a shot which is blocked by Fred.
Tuanzebe defends well against Joelinton as the defender born in the Democratic Republic of the Congo continues to play well.
Diego Dalot whips in a cross for Man Utd and Schar has to head over his own bar to clear. United have a corner... can they make it count?
Referee Mike Dean blows the half-time whistle with the game level at 0-0. Meanwhile, Saint-Maximin is off the pitch receiving treatment.
The fourth official indicates two minutes of additional time to be played.
Chance! Harry Maguire has a free header from the resultant corner, but he heads Young's delivery wide of the post. The £80m man really should have given his side the lead there. In fact, Maguire is captaining the side today, not Ashley Young.
The second half is underway.
Schar goes into the referee's book for deliberate handball.
Newcastle counter attack at pace as Saint-Maximin bursts forward and finds Almiron, but the latter's shot is miles wide and rushed.
Ashley Young is down receiving treatment for a head injury.
Man Utd have a long spell of possession but they are failing to make any in-roads against an organised Newcastle side.
Sub - Andy Carroll replaces Joelinton for Newcastle (tactical).
Jetro Willems delivers a deep cross towards Carroll but it lacks accuracy. It appears Newcastle plan to go more direct towards their newly-arrived target man.
Matty James bursts away down the right and crosses low into the box, but Marcus Rashford was not anticipating the ball and was caught on his heels.
Andreas delivers an inswinging cross from the left and James narrowly fails to get on the end of it. That's a little better from Man Utd.
Sub - Diego Dalot has to go off injured for Man Utd as Marcos Rojo comes on to replace him. That's yet another injury for Solskjaer to deal with.
That change for United has seen Rojo go to centre back and Tuanzebe move out to right back.
McTominay has a shot blocked for the away side and Newcastle try to break, but Tuanzebe makes a fine challenge. That's good defending again from the 21 year old.
Yellow - Almiron has another chance to run at the back four but he tumbles under a vague challenge from Rojo and is booked for simulation.
Close! Carroll gets on the end of a cross but heads over the bar under pressure from Tuanzebe.
Sub - Juan Mata is replaced by Mason Greenwood for Manchester United.
United go close as Young runs onto Greenwood's flick but Schar makes a crucial block.
Close! Rashford is nearly presented with a clear chance but Schar again clears crucially. That's great defending from Swiss defender.
Goal for Newcastle! Willems receives on the left, keeps the ball well under pressure and tees up Matty Longstaff... and the teenager lashes a superb shot past De Gea. Newcastle 1-0 Man Utd.
Close! Young delivers from the right and Rojo heads over the bar. That was a decent opening for the visitors.
Yellow - By the way, Marcos Rojo was booked earlier for an aggressive challenge.
More good defending from Schar as Greenwood curls a cross into the box towards Rashford but the defender clears well. An excellent outing so far.
Rashford curls in a cross from the left flank but its a very poor delivery and it runs out for a goal-kick. The Man Utd forward has really struggled today.
Now Fred tries a shot from long-range for Solskjaer's side but it goes well over the bar. That looked desperate for Man Utd.
Sub: Christian Atsu replaces Allan Saint-Maximin for Newcastle.
Andreas takes a freekick for Man Utd in a good position, but the wall blocks the shot well. That's a waste.
Sub - Tahith Chong replaces Ashley Young for Man United.
Man Utd are now playing three at the back with Chong on as a left winger. The Dutch youngster gives away a foul right away on Almiron.
Newcastle launch a long ball towards Carroll and Tuanzebe has to head away for a throw-in. This will eat up more time for the Magpies.
Full time! Newcastle 1-0 Man Utd. A goal on debut from 19 year old Matty Longstaff proves the difference between the sides in a pretty poor game. Thanks for joining us.
VAR is looking at an incident as Andy Carroll appears to catch McTominay in the face with an elbow but it is deemed accidental.
Man Utd get a freekick on the left for a handball. Can they make it count?
Yedlin bursts forward on the break for Newcastle but Rojo does well. The Newcastle man appears to have cramp and The Magpies may been effectively down to ten men for the rest of his game.
McTominay makes a run into the channel for Man Utd but Clark defends well and makes the clearance.
The fourth official indicates a minimum of four additional minutes to be played. Can Newcastle hold on?
Sub - Emil Krafth replaces Almiron for Newcastle.