The teams are walking out and the iconic UEFA Champions League anthem will soon echo around the stadium!
The last time these two met at this venue, Liverpool did not register a single shot on target as they went down to the Italians. Napoli, however, have lost five of their last six matches against English opponents.
The big news for Napoli is the inclusion of Insigne who sat on the bench this weekend. Other changes sees Allan replacing Elmas and Manolas comes in for Maksimovic.
A close to full strength Reds side as Henderson and Milner provide some good experience in the midfield which sees Wijnaldum and Chamberlain left on the bench. Origi's injury sees Firmino start.
Napoli: Meret, Di Lorenzo, Koulibaly, Manolas, Mario Rui, Callejon, Fabian, Allan, Insigne, Lozano, Mertens.
Subs: Ospina, Maksimovic, Ghoulam, Elmas, Zielinski, Milik, Llorente.
Liverpool: Adrian, Alexander-Arnold, Matip, Van Dijk, Roberton, Milner, Henderson, Fabinho, Salah, Firmino, Mane.
Subs: Kelleher, Lovren, Gomez, Wijnaldum, Lallana, Oxlade-Chamberlain, Shaqiri.
Good evening and welcome to tonight's coverage as the reigning champions Liverpool begin their title defence with a tough match against Napoli at the San Paolo Stadium.
Kick off! Play is underway in Italy!
Chance! Salah has an early chance to show his speed as he gets ahead of his man, but Napoli do well to scramble before Koulibaly forces a corner which comes to nothing.
Liverpool dominating possession early on but have been a bit sloppy with it. Napoli win possession and Adrian is tested twice as Lozano forces a double save.
The Reds break and Salah almost threads a great ball through for Firmino, but Koulibably was alert to the danger. He will have a lot to do tonight if Napoli are to keep a clean sheet.
Game starting to open up a bit as Napoli have a chance to capitalize on Matips mistake but the shot from Lozano is blocked by van Dijk.
Close! Napoli again looking threatening as Mertens plays a great ball across the goal and if not for a timely intervention from van Dijk, could easily have been a tap in.
Save! Henderson finds Mane who is in a great position, but the forward's touch lets him down and the eventual shot is easily kept out by Meret.
Close! Mertens again with a good ball in which is headered behind. Napoli looking threatening down the right flank.
Napoli starting to dominate proceedings and Liverpool are finding themselves pinned down in their own half.
Alexander-Arnold and Isigne is proving to be a great tussle. The right-back does well to dispossess the forward in a promising position and Liverpool would do well to get to the break on even terms.
Chance for Salah as Liverpool get a rare chance inside the Napoli box but the forward slashes his ball wide.
Van Dijk concedes a corner as Napoli once again get behind the Liverpool backline. Everything good seems to be coming down the right for Napoli and Klopp will need to change something or they could pay for it.
Chance! Firmino comes close as he headers inches wide from a move off the corner.
HALF-TIME: NAPOLI 0-0 LIVERPOOL! All even in Italy. Napoli had a great opening half-hour before Liverpool slowly grew into the game. Both teams have had opportunities to go ahead.
Kick off! The second half is underway!
Close! Napoli should be ahead! A great ball gets clipped over the top and van Dijk can't get to it and Mertens is there, but Adrian produces a great save to keep it out!
What a chance! Liverpool are somehow still behind as Mane and Salah break and they have a two on one situation but the pass from Mane was overhit and Salah had to chase it down and it came to nothing.
Yellow! Robertson is almost predictably the first person into the book for the evening. Mertens has been giving him trouble all night but its his foul on Callejon that earns him his booking.
Yellow! This time it's Liner into the book but again it is Callejon that draws the card. Liverpools frustration really starting to show now.
Good save from Meret to push Salah's effort out after Napoli fail to clear their lines effectively.
First substitutions of the night as both teams make a change. Wijnaldum on for Milner and Zielinski on for Insigne.
Another change and this could bring a change of tactics for Napoli. Llorente is on for Lozano and we know that Llorente enjoys a Champions League goal when it counts!
Well kept out from Meret as Firmino has a go.
Penalty for Napoli! Robertson in all sorts and he sticks out a leg and Callejon goes over. It goes to VAR but the decision stands. Mertens over the ball.
GOAL, NAPOLI, MERTENS! 1-0: Adrian gets a hand to it but he can't keep it out and Napoli lead on the night!
Liverpool win a corner as they desperately push forward to try get something out of the night. Napoli have everyone inside the box and deal with the danger.
Yellow! Llorente goes into the book for a poor foul on Wijnaldum. The boards about to go up for extra time and Liverpool will be hoping for as much time as possible.
GOAL, NAPOLI, LLORENTE! 2-0: He just loves scoring in the Champions League! Van Dijk makes a terrible error with his pass for Matip and Llorente is there in a flash as he gets onto the ball and rolls it past Adrian. Game over for the Reds.
FULL-TIME: NAPOLI 2-0 LIVERPOOL! The worst possible start for the champions but a brilliant result for Napoli. They did well to keep the Reds front three as quiet as possible and were clinical when the chances arose.