Two people were killed on Friday after a bus collided into them on the N2 at Mtwalume.
KwaZulu Private Ambulance Service said a bus had collided with two pedestrians, causing another vehicle to leave the road and overturn.
One person was seriously injured and taken to hospital.
The two pedestrians sustained fatal injuries and were declared dead on the scene.
In another crash two other people were also killed on Friday night following a collision between a truck and a minibus on the R74.
The minibus was carrying five people in it when it was involved in an accident with the truck.
"Two people died on the scene while four people including the truck driver were injured and taken to Stanger Hospital from the accident scene. Two counts of culpable homicide are currently being investigated," said Road Traffic Inspectorate spokesperson, Zinhle Mali.