Cars, buildings, gates and other infrastructure were torched at the Mangosuthu University of Technology.
It is still unclear what caused the torching of infrastructure, however classes have been cancelled until further notice.
The university announced on its official Facebook page on Thursday morning that staff and students should not go to campus.
"It is with sadness and shock that the university has woken up to malicious damage on campus," reads the statement.
"Protection services has beefed up security to protect the university, staff, and students."
Boysie Zungu, eThekwini Metro Police spokesperson said they, along with the fire department, responded to the scene early on Thursday morning.
Zungu said the fire department contained the fire and the scene was cleared.
There were no students protesting or near the scene when they arrived, added Zungu.