The 47-year-old singer looked stunning in an eye-catching Marchesa gown as she was recognised at the star-studded ceremony in Los Angeles.
While Gwen opted to take her brother as her date, with Blake joining her later on in the evening, the No Doubt front woman couldn't resist paying tribute to her beau for helping her get her life back on track following her split from husband Gavin Rossdale.
Taking to the stage to collect The Icon award from James Corden, Gwen referenced Blake as she told him: "Thank you for kissing me back to life."
Read more: Watch: Gwen Stefani and Blake Shelton impress with duet on The Voice
An accompanying video of Gwen on the Glamour website went into more depth about just how the country star has helped his girlfriend in the wake of her marriage breakdown.
"This year has been mind-blowing," she said. "Just to know there was a time I looked back and went, ‘Wow, there was a time when I didn’t know how I was going to get through it’. It was really hard to get the courage...
"Taking the pain and trying to make something great out of it is what I really try to do. Right now I’m feeling a little bit like Rocky at the top of the steps with the hands up going, ‘Woah!’ I feel like a triumph because I know how hard I worked this year to get myself into a peaceful place."
Read more: Gwen Stefani is ‘in love’ with Blake Shelton
Other honourees at the ceremony included Zendaya, who was presented with The Voice for Girls gong.
Collecting the prize, the former Disney Channel star told the crowd: "Ladies, you are the leaders. You’re the future. We need you. I’m with you. We’re all with you."
Meanwhile, Bono collected the inaugural Man of the Year gong at the ceremony, accompanied by wife Ali Hewson.
The U2 singer admitted he's "really proud" to be taking home the award, with Ali adding to U.S. TV show Extra: "I am, I like a bit of woman in my man, too. The only men you can respect are the ones who fight for women, like them enough to fight for women."
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The full list of winners at the Glamour Women of the Year Awards 2016 is as follows -
The Icon: Gwen Stefani
The Record Breaker: Simone Biles
The Justice Seekers: Patrisse Cullors, Alicia Garza and Opal Tometi, the Founders of #BlackLivesMatter
Man of the Year: Bono
The Body Activist: Ashley Graham
Lifetime Achievement: Christine Lagarde
The Woman Who Stood Up to ISIS: Nadia Murad
The Fashion Force: Miuccia Prada
The Voice for Girls: Zendaya
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