The Proteas caption will not take to the pitch with his team in the upcoming home ODI series and away Test series against Australia.
AB de Villers has been ruled out of all upcoming matches because of a persistent elbow injury.
Surgery is the "only long-term solution", team manager Dr Mohammed Moosaje said in a statement, revealing the 32-year-old cricket star failed his most recent fitness test.
The skipper will likely be out for eight to 10 weeks while he recovers.
"The target is to hopefully have him back for the Sri Lanka home series over the Christmas period," said Moosaje, a doctor himself.
Read more: Doting dad AB de Villiers is smitten with his son
"We have tried the conservative management of rest, physio, rehab and cortisone infiltration into the elbow, but that has not yielded the results that we would have liked."
AB has yet to make a statement after Cricket SA's disappointing announcement. But the father of one took to Instagram to wish his wife Danielle happy birthday yesterday.
Read more: AB de Villiers’ wife has a beautiful voice! Danielle wows in duet with Aussie cricketer
"My wife, you are such a special woman, such a special mother!" he wrote. "We are so fortunate to have you in our lives... Happy birthday, here's to many more."
Last week, AB and Danielle jetted off too Mauritius with his teammates to celebrate fellow Protea Quinten de Kock's wedding to longtime love, Sasha.
Ready for the De Kock wedding! Great times
A photo posted by AB de Villiers (@abdevilliers17) on
#TeamDuminy #TeamDeVilliers #DeKockWedding ???
A photo posted by Sue Duminy (@sueduminy) on
A photo posted by Danielle de Villiers (@danielledevilliers) on